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目的 探讨 2型糖尿病与超氧化物歧化酶 (SOD)及一氧化氮 (NO)的关系。方法 采用对照研究测定 89例 2型糖尿病病人和 112例正常对照组空腹后超氧化物歧化酶 (SOD)和一氧化氮 (NO)。结果 2型糖尿病患者组的血清SOD 86 7± 9 6(NU/ml) ,NO 79 3± 2 4 5 (NU /ml) ,正常对照组SOD 112± 11 69NU/ml) ,NO 62± 19 69(NU/ml) ,两组比较 ,P值均 <0 0 5。结论 2型糖尿病患者组血清SOD明显低于对照组 ,而NO含量明显高于对照组。 2型糖尿病患者NO含量升高可能与微血管病理变化有关 ,而SOD活性下降 ,加上高血糖状态造成糖尿病人各组织损伤 ,成为糖尿病各种并发症的重要基础。临床检测SOD或NO有助于了解 2型糖尿病病理生理变化情况 ,从而辅助治疗 ,改善预后
Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) and superoxide dismutase (SOD) and nitric oxide (NO). Methods The fasting superoxide dismutase (SOD) and nitric oxide (NO) were measured in 89 patients with type 2 diabetes mellitus and 112 healthy controls. Results Serum SOD 86 7 ± 96 (NU / ml), NO 79 3 ± 2 45 (NU / ml), SOD 112 ± 11 69NU / ml in the control group, NO 62 ± 19 69 (NU / ml), P values were <0 0 5 in both groups. Conclusion Serum SOD in patients with type 2 diabetes mellitus is significantly lower than that in control group, while the content of NO is significantly higher than that in control group. The increase of NO in type 2 diabetes mellitus may be related to the pathological changes of microvessels, while the decrease of SOD activity, together with the hyperglycemia, result in the injury of diabetic tissues and become the important basis of various complications of diabetes mellitus. Clinical detection of SOD or NO helps to understand the pathophysiological changes of type 2 diabetes, thus adjuvant therapy and improve the prognosis