论文部分内容阅读
目的探讨健康男性青年服用β受体阻滞剂卡维地洛后不同血药浓度下静息坐位血压与用药前比较有无显著性变化,以评价卡维地洛的降压特点,为临床用药提供试验依据。方法对20名健康男性青年在服用卡维地洛20mg前及服药后0.5、1、2、3、4、6、8、10、24h分别测血药浓度,并监测各时间点坐位静息血压,并将数据进行统计分析。结果血压变化与血药浓度的变化没有明显相关性,与用药前血压比较有显著性降低,即P<0.01。结论卡维地洛对正常健康男性降压迅速,并可长时间维持降压作用。无明显副反应,受试者耐受性良好。
Objective To investigate whether there are significant changes in resting sitting blood pressure between healthy male youth taking beta-blocker carvedilol and before administration, so as to evaluate the antihypertensive effect of carvedilol for clinical use Provide experimental basis. Methods 20 healthy male youth before taking carvedilol 20mg and 0.5,1,2,3,4,6,8,10,24h after taking drug concentration were measured, and to monitor the sitting point at each time point resting blood pressure , And the data for statistical analysis. Results There was no significant correlation between the change of blood pressure and the change of plasma concentration, which was significantly lower than that before treatment (P <0.01). Conclusion Carvedilol is able to depress blood pressure rapidly in normal healthy men and maintain the hypotensive effect for a long time. No obvious side effects, subjects were well tolerated.