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目的：比较活动性及稳定型肺结核患者结核菌素（PPD）皮肤试验及血清NP测定结果，探讨二者在活动性肺结核中的应用价值。方法回顾分析44例活动性肺结核（活动组）和56例稳定型肺结核（稳定组）患者PPD皮肤试验及血清NP资料。结果两组患者PPD皮肤试验强度比较，差异存在着统计学意义（P<0.05）；PPD皮肤试验判定活动性肺结核的敏感性为77.27%，特异性为85.71%。活动组患者血清NP测定值为（56.53±8.18）nmol/L，高于稳定组的（29.84±6.39） nmol/L，差异有统计学意义（P<0.05）；血清NP判断活动性肺结核的敏感性为86.70%，特异性为93.00%。二者联合诊断活动性肺结核的敏感性为93.18%，特异性为94.64%。结论血清NP可作为活动性肺结核重要的辅助诊断指标，结合PPD皮肤试验，有助于活动性肺结核的早期诊断。“,”Objective To compare tuberculin (PPD) skin test and serum mopterin (NP) test results in active and stable pulmonary tuberculosis patients, and investigate the application values of the two for active pulmonary tuberculosis. Methods Data on PPD skin test and serum NP test in 44 active pulmonary tuberculosis patients (active group) and 56 stable pulmonary tuberculosis patients (stable group) was retrospectively analyzed. Results The difference in PPD skin test strength between the patients of the two groups was statistical y significant (P<0.05);the sensitivity of PPD skin test in judgment of active pulmonary tuberculosis was 77.27%, and the specificity was 85.71%. The serum NP test value in the patients of the active group was (56.53±8.18) nmol/L, was higher than that of the control group [(29.84±6.39) nmol/L], and the difference was statistical y significant (P<0.05); the sensitivity of serum NP test in judgment of active pulmonary tuberculosis was 86.70%, and the specificity was 93.00%. The sensitivity of PPD skin test combined with serum NP test in judgment of active pulmonary tuberculosis was 93.18%, and the specificity was 94.64%. Conclusion Serum NP test can be used as an important auxiliary diagnosis index for active pulmonary tuberculosis;when used combined with PPD skin test, it is helpful for early diagnosis of active pulmonary tuberculosis.