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目的探讨血吸虫肝硬化自发性腹膜炎的发生机制，观察微生态调节剂培菲康的治疗效果。方法血吸虫肝硬化并发自发性腹膜炎41例患者，口服整肠生胶囊，4粒/次，2次/d，2w为1疗程，观察治疗效果、PT恢复正常时间、肝功能好转时间及腹水复常时间（d），并与40例单纯应用抗生素对照组比较。结果两组总有效率分别为82.9%和62.5%，之间存在非常显著性（<0.01），另外两组在血氨复常时间、PT复常时间、肝功能好转时间方面存在显著性（<0.05），腹水常规恢复正常及腹水培养阴性方面存在非常显著性（<0.01）。结论培菲康可促进肠道正常菌群的恢复，改善肝功能，重塑肠道正常细菌屏障，提高血吸虫肝硬化自发性腹膜炎的治疗效果。“,”Objective Bstract purpose to discuss the occurrence mechanism of schistosomiasis cir hosis and spontaneous bacterial peritonitis and to Observe the micro ecological regulator Bifico treatment ef ect. Methods 41 patients of schistosomiasis cir hosis complicated with spontaneous bacterial peritonitis , oral Zhengchangsheng capsule, 4 capsules each time, 2 times daily, two weeks as a course of treatment, observe the treatment ef ect, PT recovery time, liver function recovery time andrecovery time of ascites (d), and control group with 40 cases treated byantibiotics. Results The total ef iciency of two groups were 82.9%and 62.5%. There was significance in between ( <0.01). Greater significance existed in the other two groups in blood ammonia recovery time, PT recovery time, improvement of liver function in terms of time ( <0.05), ascites conventional normal and ascites culture significant negative aspects ( <0.01). Conclusion Bifico can promote the recovery of normal intestinal flora, improve liver function, remodel of normal intestinal bacterial bar ier and improve the therapeutic ef ect of Schistosoma cir hosis patients with spontaneous bacterial peritonitis.