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目的探讨可调节封闭式负压引流技术联合局部氧疗对兔深Ⅱ度烫伤创面愈合的影响，为临床应用提供实验依据。方法以40只新西兰大白兔为研究对象，建立兔深Ⅱ度烫伤模型，并将创伤兔随机分为A组（常规包扎治疗）、B组（局部氧疗）、C组（可调节封闭式负压引流治疗）、D组（可调节封闭式负压+局部氧疗），观察创面的大体变化及愈合情况，记录各组创面愈合率、愈合时间。结果 A组平均愈合天数是(25.2±2.1)d，B组平均愈合天数是(23.6±1.8)d，C组的平均愈合天数是(19.8±2.2)d，D组的平均愈合天数是(16.6±1.4)d，A组与其他三组在创面愈合时间差异上有统计学意义。治疗第12~18d，A组与其他三组在创面愈合率差异上有统计学意义。结论可调节封闭式负压引流技术与局部氧疗相结合能促进兔深Ⅱ度烫伤创面愈合，是一种新的治疗深Ⅱ度烫伤创面的方式。“,”Objective To probe into the influence of Negative Pressure-Assisted Wound Therapy (RNPT) combined with Topical Oxygen Therapy (TOT) on the healing of deep second degree scalded rabbits as to provide a experimental basis for clinical application. Methods Animal models of deep second degree scalded wound were established in 40 New Zealand rabbits, which were randomly divided into four groups:group A (routine enswathement), group B (TOT), group C (RNPT) and group D (RNPT +TOT).the changes in the wound were observed, Wound healing rate and time were respectively recorded. Results The wound healing time in group D was (16.6±1.4)d,which was significantly dif erent from those of the other groups, wound healing rate was also statistical y dif erent between group D and other groups from the 12th day to 18th day after treatment. Conclusion The new combined therapy of RNPT and TOT Can facilitate deep second degree scalded wound healing.