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目的:了解壮族正常足月新生儿生理性黄疸早期血清胆红素的动态变化值,探索其与汉族的异同。方法:①用微量胆红素法测定219例壮族正常足月新生儿(1～7天)血清胆红素,将其按血清胆红素水平分为正常组和高胆组,比较两组间各种围产因素对血清胆红素的影响。②用同样方法测定280例汉族新生儿血清胆红素,将壮族、汉族新生儿分别设为研究组和对照组,比较两组间血清胆红素。结果:①壮族正常足月新生儿出生后第2～3天出现黄疸,第4天达到高峰,平均峰值为(188.29±35.87)μmol/L,≥220.5μmol/L者占22.83%,峰值的95%可信区间的上限为258.60μmol/L。男女性别两者比较:第1、2、3、7天差别无统计学意义(P>0.05),第4、5、6天差别有统计学意义(P<0.05)。②壮族新生儿血清胆红素平均峰值略高于汉族,但两组比较差别无统计学意义(P>0.05)。③在围产期因素中,壮族正常组与高胆组的比较:高胆组的母亲孕周小于正常组(P<0.01),婴儿出生体重、母亲年龄、母亲孕次两组比较差异无统计学意义(P>0.05)。结论:壮族正常足月新生儿黄疸出现的时间及峰值与汉族基本相同,亦与国内报道相似。监测壮族正常足月新生儿早期血清胆红素的动态变化,可为新生儿高胆红素血症的诊断提供依据。
Objective: To understand the dynamic changes of serum bilirubin in the early stage of physiologic jaundice in normal term newborns of Zhuang nationality, and to explore the similarities and differences between them and Han nationality. Methods: ① Serum bilirubin was measured in 219 normal full-term newborns (1-7 days) by micro-bilirubin method and divided into normal group and high-gallium group by serum bilirubin level. Various perinatal factors on serum bilirubin. ② The same method was used to measure the serum bilirubin in 280 neonates of Han nationality. The newborns of Zhuang and Han nationalities were set as study group and control group respectively. Serum bilirubin was compared between the two groups. Results: (1) Jaundice appeared on the 2nd to 3rd day after birth in normal full-term newborns of Zhuang nationality, peaked on the 4th day, the mean peak value was (188.29 ± 35.87) μmol / L, and the value of ≥220.5μmol / L was 22.83% The upper limit of% confidence interval is 258.60 μmol / L. The difference between male and female was not statistically significant (P> 0.05) on the 1st, 2nd, 3rd and 7th days, and the difference was statistically significant on the 4th, 5th and 6th day (P <0.05). ② The mean serum bilirubin peak value of Zhuang newborn was slightly higher than that of Han nationality, but there was no significant difference between the two groups (P> 0.05). ③In the perinatal period, the Zhuang normal group and the high gall group comparison: the high gall group mother’s gestational age was less than the normal group (P <0.01), the baby’s birth weight, the mother’s age, the mother’s pregnancy times between the two groups showed no statistical difference Significance (P> 0.05). Conclusion: The time and peak value of jaundice in normal term neonates of Zhuang nationality are basically the same as that of Han nationality and also similar to those reported in China. Monitoring the dynamic changes of early serum bilirubin in normal full-term newborns of Zhuang nationality may provide a basis for the diagnosis of neonatal hyperbilirubinemia.