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目的探讨慢性非细菌性前列腺炎/慢性盆底疼痛综合征(CAP/CPPS)的治疗方法。方法对60例诊断为CAP/CPPS的患者使用非甾体类抗炎药直肠栓剂吲哚美辛栓及三唑吡啶类抗抑郁药曲唑酮进行8周的联合治疗。在治疗前、治疗后4周及8周对所有患者进行NIH-CPSI症状评分和EPS-WBC计数,对其中伴精液参数异常和性功能下降的患者分别进行精液参数测定和性功能评价。观察疗效及不良反应情况。结果60例患者在治疗后4周及8周NIH-CPSI评分和EPS-WBC较治疗前明显降低(P<0.001);伴精液参数异常和性功能下降的患者的射精潜伏期及IIEF-5评分较治疗前有明显改善(P<0.01);不良反应发生率较低。结论吲哚美辛栓联合曲唑酮的治疗方案安全有效,可以明显缓解CAP/CPPS患者症状,对患者精液质量及性功能亦有明显改善。
Objective To investigate the treatment of chronic non-bacterial prostatitis / chronic pelvic pain syndrome (CAP / CPPS). Methods Sixty patients diagnosed as CAP / CPPS were treated with indometacin suppository and triazolopyrazole antidepressant trazodone for 8 weeks by non-steroidal anti-inflammatory drugs. All patients were screened for NIH-CPSI and EPS-WBC before treatment, 4 weeks and 8 weeks after treatment, and semen parameters and sexual function were evaluated in patients with abnormal sperm parameters and sexual dysfunction. Observe the efficacy and adverse reactions. Results The NIH-CPSI score and EPS-WBC in 60 patients at 4 and 8 weeks after treatment were significantly lower than those before treatment (P <0.001). The ejaculation latency and IIEF-5 scores of patients with abnormal sperm parameters and sexual function decreased Before treatment, there was a significant improvement (P <0.01); the incidence of adverse reactions was low. Conclusion The combination of indometacin suppository and trazodone is safe and effective. It can relieve the symptoms of patients with CAP / CPPS obviously and improve the quality and sexual function of patients.