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作者对人体液 IgG抗角蛋白自身抗体(AK auto Ab)进行检测,结果显示:IgG AK auto Ab很难通过血脑屏障,极易穿透血管壁进入上皮组织。免疫电镜观察表明,AK auto Ab与角朊细胞的反应主要定位于张力细丝和桥粒,而与其它细胞器无关。家兔硫化钠皮炎皮损及血清内AK auto Ab的动态观察提示,皮损角朊细胞胞浆内AK auto Ab的沉积和血清AK auto Ab一时性降低,主要与角朊细胞的损伤有关。
The authors tested human IgG anti-keratin autoantibodies (AK auto Ab) and found that IgG AK auto Ab can not easily cross the blood-brain barrier and penetrate into the epithelium. Immunoelectron microscopy showed that AK auto Ab reacts with keratinocytes mainly in tension filaments and desmosomes, but not with other organelles. The dynamic observation of AK auto Ab in rabbit skin with sodium sulfide dermatitis and serum showed that the deposition of AK auto Ab in cytoplasm of keratinocytes and the serum level of Ak auto Ab decreased at one time and mainly related to the damage of keratinocytes.