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本文研究了白细胞介素-1(IL-1)对大肠杆菌的作用。根据对正常人血清杀菌作用的敏感性不同,将革兰氏阴性杆菌分为毒株和无毒株。在人IL-1β存在下进行培养,结果毒株的集落形成单位(CFU)增加,而无毒株没有变化。肿瘤坏死因子(TNF)和IL-4(浓度为1～1000ng/ml)对毒株和无毒株的生长均无促进作用。在RPMI-1640培养基中研究IL-1对细菌生长的作用,到达静止期前的生长对数期内可观察到IL-1β的促进生长作用高于对照组(没有加入IL-1)。IL-1α与IL-1β作用相似;对于无毒株的生长,是
This article studies the effect of interleukin-1 (IL-1) on E. coli. Gram-negative bacilli were divided into strains and non-toxic strains according to their sensitivity to the bactericidal effect of normal human serum. Cultivation in the presence of human IL-1β resulted in an increase in colony forming units (CFU) of the strain, with no change in the non-virulent strain. Tumor necrosis factor (TNF) and IL-4 (concentration of 1 ~ 1000ng / ml) had no effect on the growth of both virulent and virulent strains. The effect of IL-1 on bacterial growth was investigated in RPMI-1640 medium, and IL-1β was observed to be more rapidly promoted than that of the control (without addition of IL-1) during the logarithmic growth phase before reaching quiescence. IL-1α and IL-1β role similar; for non-toxic strains of growth, yes