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目的 研究血清性激素水平与脑卒中病情程度及预后的关系。方法 采用放射免疫法测定老年急性脑卒中 12 7例及对照组 39例的性激素水平。结果 脑卒中组男性血清雌二醇 (E2 )明显比对照组高 (P<0 .0 5 ) ,女性血清睾酮 (T)比对照组高 (P <0 .0 5 ) ;脑卒中组男性T水平及女性E2 水平与对照组比较均无显著性差异。脑卒中患者性激素水平与病情程度无关 ,但与疾病的预后有关 ,即预后越好 ,E2 升高、T降低 ,E2 /T值上升越明显。结论 E2 对脑卒中患者的受损脑细胞可能具有保护作用 ,而T具有加重脑损害的可能。E2 /T值对预测脑卒中患者的预后具有一定的临床价值
Objective To study the relationship between serum sex hormone levels and severity of stroke and prognosis. Methods Radioimmunoassay was used to determine the levels of sex hormones in 127 senile acute stroke and 39 control subjects. Results Serum estradiol (E2) in stroke group was significantly higher than that in control group (P <0.05), serum testosterone (T) was higher in control group than in control group (P <0.05) There was no significant difference in the level of E2 between women and the control group. The level of sex hormones in stroke patients has nothing to do with the severity of the disease, but with the prognosis of the disease, the better the prognosis, the higher the E2 and the lower the T, the more obvious the E2 / T value rises. Conclusion E2 may have a protective effect on the damaged brain cells of stroke patients, while T may aggravate the brain damage. The E2 / T value has certain clinical value in predicting the prognosis of stroke patients