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为了解肝硬化惠者血浆内皮素水平的变化及病理生理作用,用特异性放射免疫分析法测定46例肝硬化及30例正常人血浆内皮素含量,B超测定门静脉直径。46例肝硬化患者血浆内皮素水平(82.68±26.09pg/ml)明显高于对照组(50.8±7.58pg/ml,P<0.05)。其中24例chid-pughB级(79.6±19.27pg/ml)和14例chid—pughC级(94.55±24.3pg/ml)血浆内皮素水平明显高于8例chid-pughA级(57.05±10.96pg/ml,P<0.05和P<0.01)。43例肝硬化患者血浆ET水平与门静脉直径有明显相关性(r=0.764,P<0.001)。结果提示肝硬化患者血浆内皮素水平随肝功能损害程度加重而升高,其与门脉高压的产生有一定关系。
In order to understand the changes of plasma endothelin levels and pathophysiological effects in patients with cirrhosis, the levels of plasma endothelin in 46 cases of cirrhosis and 30 normal individuals were determined by radioimmunoassay and the portal vein diameter was measured by B ultrasound. The plasma endothelin levels in 46 patients with cirrhosis (82.68 ± 26.09pg / ml) were significantly higher than those in the control group (50.8 ± 7.58pg / ml, P <0.05). The plasma endothelin levels of 24 cases of chid-pughB grade (79.6 ± 19.27pg / ml) and 14 cases of chid-pughC grade (94.55 ± 24.3pg / ml) were significantly higher than those of 8 cases of chid-pughA grade (57.05 ± 10.96pg / ml) , P <0.05 and P <0.01). Plasma ET levels in 43 patients with cirrhosis were significantly correlated with portal vein diameter (r = 0.764, P <0.001). The results suggest that plasma endothelin levels in patients with cirrhosis increase with the severity of liver dysfunction, which is related to the occurrence of portal hypertension.