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血清脂蛋白脂类的水平与冠心病(CHD)的关系为Barr首先发现。大量的流行病学调查证实,血清高密度脂蛋白胆固醇(HDL-ch)水平与CHD呈明显的负相关。一些学者发现,血清HDL-ch测定值对近、远期CHD易患性的预测,优于单项总胆固醇(T-ch)、总甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-ch)。这些研究为CHD的早期诊断和预防治疗提供了重要线索。血清HDL-ch水平与CHD易患性的关系血清HDL-ch水平与CHD易患性呈负相关的资料主要来自美国、挪威和以色列等国家的流行病学调查。美国Framingham对2815人(年龄49～82)进行了近四年随访,当血清HDL-ch由65～74mg/dl降到25～34mg/dl时,男子的CHD发病率由2.5%升为
The relationship between serum lipoprotein lipids and coronary heart disease (CHD) was first discovered by Barr. A large number of epidemiological investigations confirmed that the level of serum high-density lipoprotein cholesterol (HDL-ch) was significantly negatively correlated with CHD. Some scholars have found that the predictive value of serum HDL-ch for both short-term and long-term CHD is superior to that of individual total cholesterol (T-ch), total triglyceride (TG) and low-density lipoprotein cholesterol ). These studies provide important clues to the early diagnosis and prevention of CHD. Serum HDL-ch levels and CHD susceptibility The relationship between serum HDL-ch levels and CHD susceptibility were mainly from epidemiological surveys in the United States, Norway and Israel. Framingham, United States of 2815 people (aged 49 to 82) were followed up for nearly four years, when the serum HDL-ch from 65 ~ 74mg / dl down to 25 ~ 34mg / dl, the incidence of CHD in men increased from 2.5%