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1.药动学 氧氟沙星(OFLX)口服主要通过小肠吸收,吸收完全。除脑组织外,广泛分布于体液和各组织器官中。生物利用度为85～95％。连续用药无积蓄倾向,但肌酐清除率<50ml/min时应调整剂量或给药间隔时间。本品主要以原药经肾排泄,48h尿药回收率高达90％,尿药浓度明显超过引起尿路感染所有病原菌的MIC(最低抑菌浓度),并至少维持12h。本药t1/2为5～8h,蛋白结合率为6.3～30％,食物
1. Pharmacokinetics Ofloxacin (OFLX) orally absorbed mainly through the small intestine, absorbed completely. In addition to brain tissue, widely distributed in body fluids and various tissues and organs. Bioavailability of 85 to 95%. Continuous medication no savings tendency, but creatinine clearance rate <50ml / min should adjust the dose or dosing interval. This product is mainly excreted by the original drug by the kidney, 48h urinary drug recovery rate of up to 90%, urinary concentration significantly exceeded all pathogens causing urinary tract infections MIC (minimum inhibitory concentration) and maintained at least 12h. The drug t1 / 2 is 5 ~ 8h, the protein binding rate of 6.3 to 30% of food