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通过观察IH764-3对培养成纤维细胞的生长曲线、3H-TdR参入、钙调素水平、生长周期DNA含量、3H-脯氨酸参入、纤维连结蛋白、血小板凝血酶敏感蛋白含量及超微结构的影响,证明IH764-3对成纤维细胞增殖及其胶原等基质合成与分泌功能有直接的抑制作用,探讨了IH764-3抗纤维化的部份作用机理。
By observing the growth curve of fibroblasts cultured with IH764-3, 3H-TdR incorporation, calmodulin level, DNA content in the growth cycle, 3H-proline incorporation, fibronectin, thromboplastin-sensitive protein content and ultrastructure IH764-3 proved that fibroblast proliferation and proliferation of collagen and other substrates have a direct inhibitory effect on the synthesis of anti-fibrosis IH764-3 part of the mechanism of action.