p53 Gene Mutations in Asbestos Associated Cancers

• 作 者: LIUBING－C1 FUDE－CHEN 等
• 机 构: InstituteofOccupationalMedicine,InstituteofOccupatio
• 出 处: 生物医学与环境科学：英文版
• 发表日期: 1998年3期
• 关键词: 石棉相关肺癌 职业风险因子 P53基因突变 PCR SSCP 免疫组织化学

The accumulation of mutant p53 protein in cancer cells was observed by immunohistochemistry analsis.DNA was extracted from paraffin-embedded tissue.Exons 5,7 and 8 were amplified and studied by PCR-SSCP and sequencing analysis.Ten cases of asbestos associ