论文部分内容阅读
目的:探讨血管内皮生长因子(VEGF)与妊娠肝内胆汁淤积症(ICP)发病的关系。方法:采用酶联免疫吸附试验(ELISA)检测30例ICP孕妇(观察组)和30例正常孕妇(对照组)静脉血清、羊水和脐静脉血清VEGF的表达水平。结果:观察组孕妇静脉血清、羊水和脐静脉血清VEGF的表达水平与对照组相比明显降低,差异有统计学意义(P<0.01)。结论:VEGF表达水平的显著下降可能是ICP发病机制中的一个重要因素。
Objective: To investigate the relationship between vascular endothelial growth factor (VEGF) and pregnancy induced intrahepatic cholestasis (ICP). Methods: The serum VEGF, amniotic fluid and umbilical vein of 30 pregnant women (observation group) and 30 normal pregnant women (control group) were detected by enzyme linked immunosorbent assay (ELISA). Results: The expression of VEGF in serum of pregnant women in observation group was significantly lower than that in control group (P <0.01). Conclusion: The significant decrease of VEGF expression may be an important factor in the pathogenesis of ICP.