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目的:评价阿德福韦酯片对老年失代偿期乙型肝炎肝硬化患者的临床疗效。方法:选择2013年10月—2014年11月间感染科收治的失代偿期乙型肝炎肝硬化患者88例,将其分为对照组44例和治疗组44例;对照组患者给予常规对症治疗,治疗组患者在对照组患者治疗基础上给予阿德福韦酯片治疗;比较两组患者治疗后的临床疗效、肝功能、凝血功能、白蛋白、Chidl-Pugh评分值及并发症的发生情况。结果:治疗后,治疗组患者的血清丙氨酸转移酶(ALT)、血白蛋白(ALB)、血清总胆红素(TBIL)、肾功能、凝血酶原时间(PT)和Chitd-Pugh评分值均明显得到改善;治疗组患者的ALT、ALB、TBIL、PT和Child-Pugh评分值均明显优于对照组(P<0.05),病毒学、生化学应答率均高于对照组(P<0.05),不良反应的发生率显著低于对照组(P<0.05)。结论:阿德福韦酯片用于治疗老年失代偿期乙型肝炎肝硬化患者的临床疗效优于常规对症治疗,有效地提高了治疗的总有效率,降低了并发症,改善了肝功能。
Objective: To evaluate the clinical efficacy of adefovir dipivoxil tablets in elderly patients with decompensated hepatitis B cirrhosis. Methods: From October 2013 to November 2014, 88 patients with decompensated hepatitis B cirrhosis admitted in the Infectious Diseases Department were divided into control group (44 cases) and treatment group (44 cases). Patients in the control group were given conventional symptomatic treatment The patients in the treatment and treatment groups were treated with adefovir dipivoxil on the basis of the treatment of the patients in the control group. The clinical efficacy, liver function, coagulation function, albumin, Chidl-Pugh score and complications were compared between the two groups Happening. Results: After treatment, the levels of ALT, ALB, TBIL, renal function, prothrombin time (PT) and Chitd-Pugh score The values of ALT, ALB, TBIL, PT and Child-Pugh scores of the treatment group were significantly better than those of the control group (P <0.05), and the virological and biochemical response rates were higher than those of the control group (P < 0.05). The incidence of adverse reactions was significantly lower than that of the control group (P <0.05). Conclusion: Adefovir dipivoxil tablets are superior to conventional symptomatic treatment in the treatment of elderly patients with decompensated hepatitis B cirrhosis, effectively increasing the total effective rate of treatment, reducing the complications and improving the liver function .