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目的:比较芬太尼透皮贴与吗啡缓释片中、重度癌性疼痛患者镇痛作用的疗效。方法:选取2014年9月—2015年9月收治中、重度癌性疼痛患者80例,采用数字表法将其分为芬太尼组(n=40)和吗啡组(n=40);芬太尼组患者给予芬太尼透皮贴镇痛治疗,吗啡组患者给予吗啡缓释片镇痛治疗,比较两组患者治疗后的镇痛的药物用量和治疗前后疼痛的缓解率。结果:芬太尼组患者治疗后的疼痛缓解率为85.00%,略高于吗啡组为82.50%(P>0.05);两组患者治疗后的生活质量评分值经比较其差异无统计学意义(P>0.05);芬太尼组患者用药后便秘、恶心、呕吐、眩晕等不良反应的发生率低于吗啡组(P<0.05),瘙痒率高于吗啡组(P<0.05)。结论:采用芬太尼透皮贴治疗中、重度癌性疼痛患者的镇痛疗效优于吗啡缓释片,减少了用量获得同吗啡一致的镇痛疗效。
Objective: To compare the analgesic effects of fentanyl transdermal patches and morphine sustained-release tablets in patients with severe cancer pain. Methods: From September 2014 to September 2015, 80 patients with moderate to severe cancer pain were selected and divided into fentanyl group (n = 40) and morphine group (n = 40) Patients in the group receiving TA were treated with transdermal patch analgesia of fentanyl and those in morphine group were treated with morphine sustained release tablets. The amount of analgesic drugs and pain relief before and after treatment were compared between the two groups. Results: The pain relief rate in the fentanyl group was 85.00% after treatment, which was slightly higher than that in the morphine group (82.50%) (P> 0.05). There was no significant difference in the quality of life scores after treatment between the two groups P> 0.05). The incidences of adverse reactions such as constipation, nausea, vomiting and dizziness were lower in the fentanyl group than those in the morphine group (P <0.05). The rate of itching in the fentanyl group was higher than that in the morphine group (P <0.05). Conclusion: The analgesic efficacy of transdermal fentanyl in patients with moderate or severe cancer pain is better than that of morphine sustained-release tablets, and the analgesic efficacy of the same amount of morphine is reduced.