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伍用磷酸咯萘啶(咯)500ml基质、磺胺多辛(磺)1 000mg乙胺嘧啶(乙)50mg及咯500mg、磺1500和乙75mg,1次给药,分别治疗急性恶性疟40例和32例。2个剂量组的平均退热时间为1.5d,平均无性体原虫转阴时间为2d。于28d内随访3～4次的治愈率,3组均为100％。配子体率,治后14d为82.5％,28d虽仍为71.9％但密度已下降89.2％。以治后不同时间配子体阳性的志愿者感染大劣按蚊,6例中1例喂蚊吸血后,在蚊涎腺内查见子孢子。
Wu with pyronaridine phosphate (slightly) 500ml matrix, sulfadoxine (sulfa) 1 000mg pyrimethamine (B) 50mg and slightly 500mg, sulfo 1500 and B 75mg, 1 dose, respectively, 40 cases of acute falciparum malaria and 32 cases. The average antipyretic time of the two dose groups was 1.5 days, and the average time for the elimination of the protozoa was 2 days. Followed up for 3 to 4 times within 28 days, the cure rate was 100% in 3 groups. Gametophyte rate, after treatment 14d 82.5%, 28d although still 71.9% but the density has dropped 89.2%. Anopheles sinensis was infected with gametophyte-positive volunteers at different times after treatment, and sporozoites were found in the mosquito salivary glands after one case of 6 mosquito-sucking vials.