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目前洋地黄仍是治疗充血性心力衰竭的主要药物之一。由于洋地黄的长期应用,人们对洋地黄的作用与副作用已有了较明确的了解。近年来的研究中注意到:洋地黄能直接作用于动脉及静脉的血管平滑肌和间接作用于骨胳肌血管的交感神经α-受体,使周围血管阻力增加。在治疗心力衰竭时,开始使心脏排出量增加,但随着洋地黄化作用于周围血管的结果,则出现心脏排出量减少,给治疗心力衰竭带来了不利条件。加之久服洋地黄对窦房结和房室束传导均产生不同程度的抑制作用,可导致室性心律紊乱和消化道等症状。因此,洋地黄的应用就受到限制,特别是心力衰竭伴心动过缓或房室传导
At present, digitalis is still one of the main drugs for treating congestive heart failure. Due to the long-term use of digitalis, people have a clearer understanding of the effects and side effects of digitalis. In recent years, the study noted that: digitalis can act directly on the arteries and veins of vascular smooth muscle and indirect effects on the skeletal muscle vascular sympathetic α-receptors, the peripheral vascular resistance increased. In the treatment of heart failure, cardiac output began to increase, but with digitalis effects on the peripheral blood vessels, there is a decrease in cardiac output, to the treatment of heart failure has brought adverse conditions. Plus long service digitalis on sinus node and atrioventricular bundle conduction have different degrees of inhibition, can lead to ventricular arrhythmia and other symptoms of the digestive tract. Therefore, the application of digitalis is limited, especially heart failure with bradycardia or atrioventricular conduction