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目的:比较双时相门冬胰岛素30两种给药方式对2型糖尿病患者临床疗效的影响。方法:76例2型糖尿病患者分为两组各38例。A组三餐前使用双时相门冬胰岛素30,B组早晚餐前使用双时相门冬胰岛素30,均治疗12周。观察两组治疗前后空腹及餐后2h血糖、C肽浓度,比较两组血糖达标时间、低血糖发生次数、糖化血红蛋白、三酰甘油和胆固醇水平。结果:治疗后,A组血糖达标时间明显低于于B组(P<0.05),两组胰岛素日用量、低血糖发生次数差异无统计学意义(P>0.05)。两组均无严重低血糖的发生。两组糖化血红蛋白、三酰甘油和胆固醇水平均较治疗前明显下降,且治疗后A组明显低于B组(P<0.05)。两组患者血糖均较治疗前明显下降,C肽水平则较前升高(P<0.05)。A组与B组相比,空腹及餐后2 h血糖差异无统计学意义(P>0.05);空腹及餐后2 hC肽水平差异有统计学意义(P<0.05)。结论:1日3次使用双时相门冬胰岛素30是一种更安全有效改善患者血糖水平的方法,值得临床推广应用。
OBJECTIVE: To compare the clinical effects of two administrations of insulin aspart 30 in patients with type 2 diabetes mellitus (T2DM). Methods: 76 cases of type 2 diabetes were divided into two groups of 38 cases. A group of three meals before the use of double-phase aspart insulin 30, B group before breakfast and evening meal using double-phase insulin aspart 30, were treated for 12 weeks. The fasting and postprandial blood glucose and C-peptide concentrations were observed before and after treatment in two groups. The time of reaching the goal of blood glucose, the number of hypoglycemia, glycosylated hemoglobin, triglyceride and cholesterol levels were compared between the two groups. Results: After treatment, the time of reaching blood glucose in group A was significantly lower than that in group B (P <0.05). There was no significant difference in the daily dosage of insulin and the number of hypoglycemia between two groups (P> 0.05). No severe hypoglycemia occurred in either group. The levels of glycosylated hemoglobin, triglyceride and cholesterol in two groups were significantly lower than those before treatment, and the A group was significantly lower than the B group after treatment (P <0.05). Blood glucose in both groups were significantly lower than before treatment, C-peptide levels were higher than before (P <0.05). There was no significant difference in fasting blood glucose and 2-h postprandial blood glucose between group A and group B (P> 0.05). There was a significant difference in fasting and postprandial 2-h peptide levels (P <0.05). Conclusion: Three times a day using double-phase aspart insulin 30 is a safer and effective way to improve blood glucose levels, worthy of clinical application.