论文部分内容阅读
目的 应用冠脉血流显像技术结合潘生丁药物负荷试验对单纯高脂血症患者的冠脉血流储备（ＣＦＲ） 进行评价，探讨血脂对ＣＦＲ的影响。方法 研究对象分为单纯高脂血症组（Ａ 组，３０ 例） 和正常对照组（Ｂ 组，１５ 例），应用冠脉血流显像技术检测每位受试者静息时的冠脉血流频谱及静脉推注潘生丁（０－５６ｍｇ／ｋｇ） 后的冠脉血流频谱，分别用最大充血状态下与静息时的冠脉峰值血流速度（ＣＰＶ） 比值及速度时间积分（ＶＴＩ） ×心率（ＨＲ） 比值来计算ＣＦＲ。结果 静息时，两组的ＣＰＶ 及ＶＴＩ×ＨＲ 无明显差别（Ｐ＞ ０－０５）。潘生丁负荷后两组的冠脉血流速度均明显加快，但Ａ组的ＣＰＶ 及ＶＴＩ×ＨＲ 增加程度低于Ｂ 组。两组的ＣＦＲ 值有显著性差别，Ａ 组明显低于Ｂ 组（ Ｐ＜０－０１） 。相关性分析显示ＣＦＲ与ＴＣ、ＬＤＬＣ呈显著负相关（Ｐ＜ ０－０５） 。结论 应用冠脉血流显像新技术结合潘生丁药物负荷试验无创性检测ＣＦＲ，可以早期发现高脂血症患者的冠脉储备功能异常，为指导治疗与评估各种降脂措施的疗效提供重要依据
Objective To evaluate coronary flow reserve (CFR) in patients with hyperlipidemia by coronary flow imaging combined with dipyridamole drug load test to investigate the effect of blood lipid on CFR. Methods The subjects were divided into hyperlipidemia group (A group, 30 cases) and normal control group (B group, 15 cases). Coronary flow imaging was used to detect the resting coronary artery The coronary artery blood flow spectrum after dipyridamole (0-56mg / kg) was intravenously injected into the bloodstream and the peak coronary flow velocity (CPV) ratio and the velocity time integral (VTI ) × heart rate (HR) ratio to calculate CFR. Results At rest, there was no significant difference in CPV and VTI × HR between the two groups (P> 0-05). Coronary blood flow velocity was significantly increased in both groups after dipyridamole load, but the increase in CPV and VTI × HR in group A was lower than that in group B. There was a significant difference in CFR between the two groups, which was significantly lower in group A than in group B (P <0-01). Correlation analysis showed that CFR and TC, LDL C was significantly negative (P <0-05). Conclusion Coronary artery perfusion imaging combined with dipyridamole drug load test non-invasive detection of CFR can be early detection of coronary artery reserve dysfunction in patients with hyperlipidemia, to guide the treatment and evaluation of various lipid-lowering measures to provide an important basis for the efficacy