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人体免疫系统面对快速变化的机体内外环境因素严重不适应,导致炎症和免疫反应的错误或者过度活化,进而诱发相应组织器官的损伤与变性等自身免疫性疾病的病理发生过程。而某些寄生性蠕虫在与其宿主长期共同进化过程中获得了有效调控其哺乳动物宿主炎症免疫反应的能力,使宿主能够免于因炎症免疫反应过度活化造成的组织与器官的损伤。因此,有关蠕虫和蠕虫源性免疫调控性分子在自身免疫性疾病治疗中的应用已成为近年来的热点。本文就此进行综述与探讨,并展望了蠕虫和蠕虫源性免疫调控性分子的临床应用前景。
In the face of rapidly changing internal and external environmental factors, the immune system of the human body is seriously ill-adapted, resulting in errors or over-activation of inflammation and immune responses, thereby inducing the pathological process of autoimmune diseases such as injury and degeneration of corresponding tissues and organs. Some parasitic worms acquire the ability to effectively regulate the inflammatory immune response of mammalian host during its long-term co-evolution with their host, so that the host can be protected from tissue and organ damage caused by over-activation of inflammatory immune response. Therefore, the application of worms and worm-derived immunomodulatory molecules in the treatment of autoimmune diseases has become a hot spot in recent years. This article reviews and discusses this issue and looks forward to the clinical application of worms and worm-derived immunomodulatory molecules.