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目的:探讨CD44v6在胃癌发展与预后中的作用。方法:采用抗CD44v6单克隆抗体和ABC法检测了96例胃癌标本,并研究了CD44v6表达与胃癌临床病理特征间的关系。结果:正常胃粘膜中,部分胃腺体中下部细胞的胞膜染色呈棕红色。31％(30/96)的胃癌被染色,免疫反应位于肿瘤的细胞膜上。CD44v6的总阳性率在硬化型胃癌显著较高。CD44v6的强阳性率于浸润型胃癌及胃癌伴有淋巴结转移者均显著升高。CD44v6强阳性者术后5年生存率显著降低。结论:CD44v6的过度表达很可能参与促进了胃癌的浸润,并且可影响患者的预后。
Objective: To investigate the role of CD44v6 in the development and prognosis of gastric cancer. METHODS: Ninety-six gastric cancer specimens were detected by anti-CD44v6 monoclonal antibody and ABC method, and the relationship between CD44v6 expression and clinicopathological features of gastric cancer was studied. RESULTS: In the normal gastric mucosa, the membranous staining of the lower and middle gastric glands was brown-red. Thirty-one percent (30/96) of gastric cancers were stained and the immune response was located on the tumor’s cell membrane. The total positive rate of CD44v6 was significantly higher in sclerosing gastric cancer. The strong positive rate of CD44v6 was significantly higher in invasive gastric cancer and gastric cancer with lymph node metastasis. The 5-year survival rate of CD44v6 strongly positive patients decreased significantly. CONCLUSIONS: Overexpression of CD44v6 is likely to contribute to the infiltration of gastric cancer and may affect the patient’s prognosis.