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目的探讨免疫球蛋白治疗新生儿感染性肺炎临床效果。方法选择2012年1月-2015年1月铜陵市第四人民医院收治的80例感染性肺炎新生儿为研究对象,按照数字表法分为对照组与观察组,每组各40例。对照组患儿使用乳糖酸红霉素及其他常规手段治疗,观察组在对照组基础上联合免疫球蛋白治疗。对比两组患者体征及临床症状缓解时间、治疗有效率、免疫学指标等临床指标。结果观察组哮鸣音、咳嗽、肺部湿啰音改善时间、住院时间、退热时间分别为均明显短于对照组(均P<0.01);观察组治疗后PaO_2、PaCO_2、TcSaO_2改善均优于对照组,差异有统计学意义(P<0.05);观察组治疗有效率为95.00%,对照组为82.50%,两组比较,差异有统计学意义(χ~2=3.851,P<0.05);观察组治疗后IgG、IgG2、IgG4改善均优于对照组,差异有统计学意义(P<0.05)。结论免疫球蛋白治疗新生儿感染性肺炎临床效果好,利于改善患儿临床症状,提升免疫力,促进恢复。
Objective To investigate the clinical effect of immunoglobulin in the treatment of neonatal pneumonia. Methods From January 2012 to January 2015, 80 infants with infectious pneumonia admitted to the Fourth People’s Hospital of Tongling City were selected as control group and control group according to digital table method, 40 cases in each group. Control children with erythromycin lactobionate and other conventional treatment, the observation group in the control group based on the combination of immunoglobulin treatment. Two groups of patients with signs and clinical symptoms of remission, treatment efficiency, immunological indicators and other clinical indicators. Results The improvement time of wheeze, cough and pulmonary arachnoid in the observation group were significantly shorter than those in the control group (all P <0.01). PaO2, PaCO_2 and TcSaO_2 in the observation group were both improved The difference between the two groups was statistically significant (χ ~ 2 = 3.851, P <0.05). The difference was statistically significant (P <0.05). The effective rate of the observation group was 95.00% and that of the control group was 82.50% The improvement of IgG, IgG2 and IgG4 in the observation group was better than that in the control group, the difference was statistically significant (P <0.05). Conclusion Immunoglobulin is effective in treating neonatal pneumonia with pneumonia. It will help to improve clinical symptoms, enhance immunity and promote recovery.