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目的:观察西立伐他汀对高胆固醇血症患者的调脂作用,并与辛伐他汀比较。方法:32例高胆固醇患者随机分为两组,服药前及服药后4周测定血脂。结果:(1)服药后4周总胆固醇(TC)分别降低了28.9％和28.0％(P值均<0.01),低密度脂蛋白胆固醇(LDL-C)水平分别降低了31.5％和32.5％(P值均<0.01)。(2)西立伐他汀明显降低血清甘油三酯(TC)水平22.0％(P<0.05)。(3)服西立伐他汀和辛伐他汀4周后脂蛋白(α)[LP(α)]水平分别降低了35.3％(P<0.01)和27.8％(P<0.05)。结论:西立伐他汀能显著降低高胆固醇血症患者血清TC和LDL-C,其作用与辛伐他汀相等,西立伐他汀降低TG作用优于辛伐他汀。
Objective: To observe the effect of cerivastatin on lipid metabolism in patients with hypercholesterolemia and compare with simvastatin. Methods: Thirty-two patients with hypercholesterolemia were randomly divided into two groups. Blood lipids were measured before treatment and 4 weeks after taking the medicine. Results: (1) Total cholesterol (TC) decreased by 28.9% and 28.0% respectively at 4 weeks after treatment (P <0.01) and LDL-C decreased by 31.5% and 32.5% P <0.01). (2) Cerivastatin significantly reduced serum triglyceride (TC) level by 22.0% (P <0.05). (3) Serum lipids (LP) decreased by 35.3% (P <0.01) and 27.8% (P <0.05), respectively, after 4 weeks of treatment with cerivastatin and simvastatin. Conclusion: Cerivastatin can significantly reduce the serum TC and LDL-C in patients with hypercholesterolemia, its role is equivalent to that of simvastatin, and the effect of cerivastatin on TG is better than simvastatin.