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左旋18甲基炔诺酮抑制性激素结合球蛋白(SHBG)减少可导致游离左旋18甲基炔诺酮指数(FLI)增加。任何途径给与左旋18甲基炔诺酮均引起血循环中SHBG下降,而SHBG又影响左旋18甲基炔诺酮的血浓度。Norplant埋植时,被药物饱和的胶囊壁大量释放左旋18甲基炔诺酮,其分子弥散入外周组织间液,再进入毛细血管和血循环,以后逐渐形成动态平衡,每天恒定缓慢释放。目前尚不清楚埋植后左旋18甲基炔诺酮为何引起SHBG下降。本文研究了Norplant埋植后一周内SHBG和左旋18甲基炔诺酮的血浆水平,并测定FLI。 Norplant埋植剂为6支/套,每支直径2.4 mm,长3.3 cm,含36 mg左旋18甲基炔诺酮,于上臂内侧局部麻醉后埋入,使用期5
A decrease in levonorgestrel 18 inhibiting sex hormone-binding globulin (SHBG) results in an increase in free left-handed 18-norethisterone index (FLI). Anyway, administration of levonorgestrel 18 nor-norethindrone causes a decrease in SHBG in the blood circulation, which in turn affects the blood concentration of levonorgestrel 18 norgestrel. When Norplant was implanted, the capsule wall saturated with the drug released a large amount of levonorgestrel 18, and its molecules diffused into the interstitial fluid in the periphery and then into the capillaries and blood circulation. After that, a dynamic balance was gradually formed and was released slowly and steadily daily. It is not yet clear why SH-PG decreased after implantation of 18-norgestrel. This study investigated the plasma levels of SHBG and 18-norgestrel within one week after Norplant implantation and determined FLI. Norplant implants 6 / set, each diameter 2.4 mm, length 3.3 cm, containing 36 mg of 18-norgestrel, embedded in the medial upper arm after local anesthesia, the use of 5