上海地区汉族人5-HT2a受体基因T102C多态性的基因频率分布

• 作 者: 罗星光 江三多 江开达 顾牛范 林嗣萃 钱伊萍
• 机 构: 上海医科大学精神医学教研室,上海市精神卫生研究所遗传室
• 出 处: 遗传
• 发表日期: 1998年05期
• 关键词: 受体基因 HT2a T102C 基因频率 多态性 中国汉族人 法医学鉴定 杂合度 关联研究 氨基酸结构

为了揭示中国汉族人５－ＨＴ２ａ受体基因Ｔ１０２Ｃ多态性基因频率的分布，我们随机抽取了２２６例汉族健康人作研究，用限制性片段长度多态性（ＲＦＬＰｓ）技术测定研究对象的基因型和等位基因。结果发现汉族正常人５－ＨＴ２ａ受体基因Ｔ１０２Ｃ多态性基因型频率依次为：Ａ１／Ａ２＝０５０４４，Ａ１／Ａ１＝０２９６５，Ａ２／Ａ２＝０１９９１，两种等位基因频率依次为：Ａ１＝０５４８７，Ａ２＝０４５１３，杂合度Ｈ＝０５０４４、期望杂合度ｈ＝０４９５３、多态信息量ＰＩＣ＝０３７２６，表明Ｔ１０２Ｃ多态性具有合适信息，对疾病的关联研究、法医学鉴定有一定的价值

To reveal the distribution of the T102C polymorphism gene frequency of 5-HT2a receptor gene in Chinese Han population, we randomly selected 226 Han healthy subjects and determined the genotypes of the subjects by RFLP (restriction fragment length polymorphism) And alleles. The results showed that the genotype frequencies of 5-HT2a receptor gene T102C in Han normal population were A1 / A2 = 05044, A1 / A1 = 02965, A2 / A2 = 0.1991. The two alleles The order of the frequency was A1 = 05487, A2 = 04513, heterozygosity H = 05044, expected heterozygosity h = 04953, polymorphism information PIC = 03726, which indicated that T102C polymorphism was suitable Information, research on the relationship between the disease, forensic identification has some value