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目的研究咪达唑仑联合亚低温治疗对小儿重症病毒性脑炎疗效及预后的影响。方法选取本院50例重症病毒性脑炎随机分为咪达唑仑联合亚低温组及常规治疗组。其余治疗相同。比较两组的临床症状恢复时间、血生化改变、并发症及预后的差异。结果咪达唑仑联合亚低温组患者临床疗效优于常规治疗组,亚低温组的病死率、致残率和治愈率均明显优于常规治疗组。结论持续咪达唑仑泵入联合亚低温治疗能显著改善小儿重症病毒性脑炎的临床恢复时间,减少并发症,改善预后和提高生活质量。
Objective To investigate the effect of midazolam combined with mild hypothermia on the efficacy and prognosis of pediatric severe viral encephalitis. Methods Fifty patients with severe viral encephalitis in our hospital were randomly divided into midazolam combined with mild hypothermia group and conventional treatment group. The rest of the treatment is the same. The differences of clinical symptoms recovery time, blood biochemical changes, complications and prognosis between the two groups were compared. Results The clinical efficacy of midazolam combined with mild hypothermia was better than that of the conventional treatment group. The mortality, morbidity and cure rate in the mild hypothermia group were significantly better than those in the conventional treatment group. Conclusion Continuous midazolam infusion combined with mild hypothermia can significantly improve the clinical recovery time, reduce the complications, improve the prognosis and improve the quality of life in children with severe viral encephalitis.