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目的探讨拉贝洛尔联合硫酸镁治疗重度子痫前期的临床疗效。方法以100例重度子痫前期患者为研究对象,随机分为观察组50例,采用拉贝洛尔联合硫酸镁进行治疗,对照组50例单纯采用硫酸镁进行治疗。治疗过程中监测并记录血压、心率、呼吸、血压取平均动脉压,治疗前24h尿蛋白定量变化及临床结局及并发症。结果观察组用药后平均动脉压明显低于用药前,相比差异有统计学意义(P<0.05),而对照组用药后平均动脉压较观察组也降低,但统计学分析差异无统计学意义(P>0.05),两组治疗后24h尿蛋白均明显低于治疗前,相比差异有统计学意义(P<0.05)。观察组胎儿窘迫、新生儿窒息及产后出血发生率明显低于对照组,相比差异有统计学意义(P<0.05)。结论应用拉贝洛尔联合硫酸镁治疗重度子痫前期的妊娠患者能迅速降低血压、减少尿蛋白、降低产科并发症的发生率,效果满意,值得在临床上推广使用。
Objective To investigate the clinical efficacy of labetalol combined with magnesium sulfate in the treatment of severe preeclampsia. Methods 100 patients with severe preeclampsia were randomly divided into observation group (n = 50) and labetalol combined with magnesium sulfate (n = 50). The control group (n = 50) was treated with magnesium sulfate alone. During treatment, blood pressure, heart rate, respiration and blood pressure were monitored and recorded. Mean arterial pressure was measured 24 hours before treatment and the clinical outcome and complications were analyzed. Results The mean arterial pressure in the observation group was significantly lower than that before treatment (P <0.05), while the mean arterial pressure in the control group was lower than that in the observation group, but the difference was not statistically significant (P> 0.05). The urinary protein in 24 hours after treatment was significantly lower than that before treatment, the difference was statistically significant (P <0.05). The incidence of fetal distress, neonatal asphyxia and postpartum hemorrhage in the observation group was significantly lower than that in the control group (P <0.05). Conclusion The combination of labetalol and magnesium sulfate in pregnant women with severe preeclampsia can rapidly lower blood pressure, reduce urinary protein, reduce the incidence of obstetric complications, with satisfactory results, which is worth popularizing in clinic.