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应用免疫组化技术检测 2 8例过敏性哮喘发作期病人外周血T细胞亚群 ,采用ELISA双抗体夹心法测定血清IgE和白细胞介素 -4 (IL -4 )水平。结果过敏性哮喘患者发作期血清IgE、IL -4水平明显升高 ,CD+ 8下降 ,CD+ 4/CD+ 8比值升高 ,与缓解期和对照组差异有高度显著性 (P <0 .0 1) ,且血清IgE与IL -4水平有明显的正相关 (r =0 .796)。说明T淋巴细胞激活及其释放的IL -4在哮喘发病中起重要作用 ,IgE合成增加是过敏性哮喘发作的关键。
Serum levels of IgE and interleukin-4 (IL-4) were measured by ELISA double antibody sandwich method in 28 peripheral blood T lymphocyte subsets of 28 patients with allergic asthma attack by immunohistochemistry. Results Serum levels of IgE and IL-4 in patients with allergic asthma were significantly higher than those in control group (P <0.01), and the levels of CD 8 and CD 4 / CD 8 were significantly increased , And there was a significant positive correlation between serum IgE and IL-4 (r = 0.796). It shows that T lymphocyte activation and IL-4 release play an important role in the pathogenesis of asthma. The increase of IgE synthesis is the key to the onset of allergic asthma.