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近些年来,基于导向策略的Pd催化间位C(sp~2)—H键活化反应取得了重要进展.人们通过远程导向策略,针对不同底物发展了多种U型导向基,在一些单保护氨基酸配体(MPAA)的协助下,实现了多种底物的烯基化、芳基化和乙酰氧基化反应.最近,人们又将Pd催化导向邻位C—H键活化和Catellani反应相结合,使用结构简单的导向基实现了高选择性的间位C—H键的烷基化和芳基化反应.这两种策略均可用于一些生物活性分子或者药物分子前体的后期修饰与合成当中.本文将针对这一领域的最新研究进展做一概述.
In recent years, Pd-based catalysis based on the guidance strategy has made significant progress in the activation of the intermolecular C (sp ~ 2) -H bond.During the long-range strategy, many kinds of U-type guide groups have been developed for different substrates, With the help of protected amino acid ligands (MPAA), a variety of substrate alkenylation, arylation and acetoxylation reactions have been achieved. Recently, Pd-catalyzed Pd-catalyzed ortho-C-H bond activation and Catellani reaction , A highly selective, meta-C-H bond alkylation and arylation reaction was achieved using a simple-oriented director.These two strategies are both useful for the later modification of some bioactive molecules or drug molecule precursors And synthesis.This article will give an overview of the latest research progress in this area.