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目的探索孟鲁司特钠联合丙卡特罗应用于慢性咳嗽患儿的临床治疗效果。方法 84例慢性咳嗽患儿,使用随机数表法分成对照组和实验组,每组42例。对照组单纯接受丙卡特罗治疗,实验组则联合孟鲁司特钠和丙卡特罗进行治疗,治疗1个月后观察两组患儿临床症状改善情况、血清免疫球蛋白E(IgE)水平改善情况及临床疗效。结果治疗1个月后,两组患儿的临床症状和血清IgE水平均得到显著改善,且实验组咳嗽开始好转时间、完全消失时间以及血清IgE水平改善效果显著优于对照组,差异有统计学意义(P<0.05);实验组临床治疗总有效率为95.2%,显著高于对照组的71.4%,差异有统计学意义(P<0.05)。结论孟鲁司特钠联合丙卡特罗能有效的缓解慢性咳嗽患儿的临床症状体征以及血清IgE水平,疗效显著,具有临床推广价值。
Objective To explore the clinical effect of montelukast combined with procaterol in children with chronic cough. Methods Eighty-four children with chronic cough were divided into control group and experimental group using random number table, with 42 cases in each group. The control group was treated with procaterol alone. The experimental group was treated with montelukast sodium and procaterol. After 1 month of treatment, the improvement of clinical symptoms and serum immunoglobulin E (IgE) level were observed Situation and clinical efficacy. Results After 1 month of treatment, clinical symptoms and serum IgE levels of both groups were significantly improved, and the improvement of cough onset time, complete disappearance time and serum IgE level in the experimental group were significantly better than the control group, the difference was statistically significant (P <0.05). The total effective rate of clinical trial in experimental group was 95.2%, which was significantly higher than that in control group (71.4%), the difference was statistically significant (P <0.05). Conclusion Montelukast combined with procaterol can effectively relieve clinical symptoms and signs and serum IgE levels in children with chronic cough, with significant curative effect and clinical promotion value.