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目的观察5-氨基酮戊酸光动力(ALA-PDT)疗法联合CO2激光治疗宫颈尖锐湿疣的疗效和安全性。方法将入选的97例患者随机分为三组,治疗组(33例)采用ALA-PDT联合CO2激光治疗,CO2激光组(32例)采用CO2激光治疗,ALA-PDT组(32例)采用ALA-PDT治疗。比较三组患者的临床疗效和安全性。结果治疗组在治疗后的治愈率和治疗后三个月的复发率为87.75%和12.12%、CO2激光组分别为56.25%和43.75%,ALA-PDT组分别为68.75%和31.25%。治疗组和CO2激光组比较其有效率差异有统计学意义(χ2=3.984,P<0.05)。三组患者均未发生不良反应。结论 ALA-PDT联合CO2激光治疗宫颈尖锐湿疣治愈率高,复发率低,安全性好,患者依从性高。较小疣体可单独使用ALA-PDT治疗。
Objective To observe the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser in the treatment of cervical condyloma acuminatum. Methods The selected 97 patients were randomly divided into three groups. The treatment group (33 cases) was treated with ALA-PDT combined with CO2 laser. The CO2 laser group (32 cases) was treated with CO2 laser. The ALA-PDT group (32 cases) -PDT treatment. The clinical efficacy and safety of the three groups were compared. Results The cure rate of treatment group and the three months after treatment were 87.75% and 12.12% respectively, 56.25% and 43.75% in CO2 laser group and 68.75% and 31.25% in ALA-PDT group respectively. There was significant difference between the treatment group and CO2 laser group (χ2 = 3.984, P <0.05). Three groups of patients were not adverse reactions. Conclusion ALA-PDT combined with CO2 laser treatment of cervical condyloma has high cure rate, low recurrence rate, good safety and high compliance. Lesser warts can be treated with ALA-PDT alone.