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目的 :评价大剂量醛氢叶酸加 5氟尿嘧啶 (5 FU)持续 4 8小时滴注方案治疗晚期大肠癌的客观疗效及毒副反应。方法 :对入选的 2 2例晚期大肠癌患者采用大剂量醛氢叶酸加 5 FU持续 4 8小时滴注方案进行治疗。结果 :2 2例患者均可进行评价 ;平均化疗 3 1个周期 ;CR 1例 ,PR 7例 ,NC 11例 ,PD 3例 ,总有效率为 36 4 %。主要的毒副反应为恶心呕吐、脱发、口腔粘膜炎、骨髓抑制及腹泻 ,大多为Ⅰ～Ⅱ度反应 ,经常规对症治疗后均见好转。结论 :大剂量醛氢叶酸加 5 FU持续 4 8小时滴注为主方案治疗晚期大肠癌疗效较好 ,毒副反应轻
Objective: To evaluate the objective curative effect and toxicity of high-dose oxytetrahydrofolate plus 5-fluorouracil (5 FU) for 48 hours in patients with advanced colorectal cancer. Methods: A total of 22 patients with advanced colorectal cancer were enrolled in the study. High-dose oxytetrahydrofolate plus 5 FU was given for 48 hours. Results: Twenty-two patients were eligible for evaluation. The average duration of chemotherapy was 31 cycles. CR 1, PR 7, NC 11 and PD 3 36%. The main side effects of nausea and vomiting, hair loss, oral mucositis, myelosuppression and diarrhea, mostly Ⅰ ~ Ⅱ degree response, after conventional symptomatic treatment were improved. CONCLUSION: High-dose oxytetrahydrofolate combined with 5 FU for 48 hours is the best choice for the treatment of advanced colorectal cancer with less toxic side effects