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目的 探讨长链非编码卵巢腺癌扩增RNA(LncRNA-OVAAL)与子宫内膜浆液性乳头状癌(UPSC)患者肿瘤复发和预后的关系.方法 选取2012年12月至2013年12月于湖北省肿瘤医院收治的UPSC患者32例为观察组,其他良性疾病切除子宫患者30例为对照组,Real-time PCR检测入组患者血清中LncRNA-OVAAL表达情况,ROC曲线分析LncRNA-OVAAL在UPSC患者血清中的截断值;分析LncRNA-OVAAL表达与临床病理特征的关系;计算UPSC患者累计生存率并进行生存分析,Cox风险回归模型进行UPSC患者预后和总生存率的单因素和多因素分析 LncRNA-OVAAL在UPSC患者血清表达升高,与患者年龄、血管侵犯情况、绝经情况、复发情况及术前血清人附睾分泌蛋白4(HEA)、糖类抗原125(CA125)有关(P＜0.05);并且LncRNA-OVAAL高表达是UPSC患者术后复发和总体生存率的危险因素(P＜0.05).结论 LncRNA-OVAAL高表达对预测UPSC患者术后复发及预后具有一定的评估价值.“,”Objective To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA (LncRNA-OVAAL) and tumor recurrence and prognosis in uterine papillary serous carcinoma (UPSC).Methods From May 2012 to November 2016,32 patients with UPSC in our hospital were selected as observation group,and 30 patients with other benign diseases were selected as control group.Real-time polymerase chain reaction (PCR) was used to detect the expression of LncRNA-OVAAL in the enrolled patients.The receiver operating characteristic (ROC) curve was used to analyze the cutoff value of LncRNA-OVAAL.The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed.The cumulative survival rate was calculated and survival analysis was performed.The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and overall survival rate.Results The expression of LncRNA-OVAAL in patients with UPSC was elevated,which was related to age,vascular invasion,menopause,recurrence and preoperative serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) (P ＜ 0.05).High expression of LncRNAOVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC (P ＜0.05).Conclusions The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC.