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作者介绍了对新生儿接种两针乙型肝炎疫苗的结果。研究在布隆迪CharlesM院的480名新生儿中进行。仅127名婴儿持续观察到12个月。疫苗接种组68人,对照组59人。所用的乙型肝炎疫苗由巴斯德研究所提供,每支1ml,含5μgHBsAg。疫苗组在新生儿初生时接种1针,2个月后接种第2针,在12个月时加强接种1针。而对照组则按常规程序接种其他疫苗。分别在出生时(T0)、出生后第4个月(T4)、第12个月(T12)和第24个月(T24)采血。疫苗组有45名婴儿在加强免疫后6个月(即T18)采血1次。另外,每组分别于T24采集19个婴儿的血样。用Abbott放射免疫(RIA)试剂盒检侧HBsAg、抗-HBs和抗
The authors describe the results of a two-dose hepatitis B vaccine on newborns. The study was conducted in 480 newborns at Charles M Institute in Burundi. Only 127 infants were observed for 12 months. 68 in the vaccination group and 59 in the control group. The hepatitis B vaccine used was supplied by the Pasteur Institute, 1 ml each, containing 5 μg HBsAg. The vaccine group was given a newborn infants with 1 needle at birth, 2 months after the second vaccination, and 12 months at the time of intensive vaccination with 1 needle. The control group is routinely vaccinated with other vaccines. Blood was collected at birth (T0), 4th month after birth (T4), 12th month (T12) and 24th month (T24) respectively. Forty-five infants in the vaccine group were bled 1 time six months after booster immunization (ie T18). In addition, blood samples from 19 infants were collected from each group at T24. HBsAg, anti-HBs and anti-HBsAg were tested using the Abbott radioimmunoassay (RIA) kit