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以体外受精-胚移植(IVF-ET)作为对不孕症的治疗自1978年英国第一例试管婴儿诞生后,已在世界各国推广,至今已有1000余例成功。在此期间,各国学者不断改进这一技术,使妊娠率得到提高。现就促卵泡发育、卵子的采取、受精、胚移植等方面近年来的进展综述如下。一、促卵泡发育及采卵方法的改进 IVF-ET的关键之一是如何采取多个成熟卵。所采取卵的成熟度对以后的受精、分离、胚移植的影响较大。Edward、Steptoe的第1例IVF-ET是采用自然周期中的卵子。Jrounson最早使用克罗米芬刺激卵泡发育并使用HCG诱发排卵。嗣后有许多作者采用了各种不同的促卵泡发育措施,目
In vitro Fertilization - Embryo Transfer (IVF-ET) as a Treatment for Infertility Since the birth of the first test-tube baby in England in 1978, it has been extended to countries around the world and more than 1,000 have been successful. During this period, scholars from various countries continuously improved this technique so that the pregnancy rate was improved. Now on the follicular development, the egg taken, fertilization, embryo transfer and other aspects of progress in recent years are summarized below. First, the development of follicular follicles and the improvement of methods of harvest IVF-ET is one of the key to how to take multiple mature eggs. The maturity of the eggs taken after fertilization, separation, greater impact on embryo transfer. The first case of Edward, Steptoe IVF-ET uses eggs in the natural cycle. Jrounson first used clomiphene to stimulate follicular development and use HCG to induce ovulation. Many authors subsequently adopted a variety of different follicular developmental strategies