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目的 总结MFL/CAV方案治疗晚期乳腺癌的疗效和毒副作用。方法 33例可评价疗效的晚期乳腺癌病人,第1天应用MFL方案:甲氨喋呤(MTX)200mg/m~2,5—氟脲嘧啶(5—Fu)500mg/m~2,24小时后用甲酰四氢叶酸钙(CF)10mg/m~2每6小时1次,共6次,第8天应用CAV方案;环磷酰胺(CTX)300mg/m~2、阿霉素(ADM)50mg/m~2 长春新碱(VCR)1mg/m~2,28天为一疗程。结果 总有效率为81.80％(27/33),其中完全缓解(CR)9.10％,部份缓解(PR)72.7％,稳定(SD)12.1％,进展(PD)6％。中位缓解期11个月,呈反应的中位数2疗程。毒副反应主要是骨髓抑制,3至4周恢复,其次是胃肠道反应和脱发。结论 应用MFL/CAV方案是治疗晚期乳腺癌最有效的方案之一。
Objective To summarize the efficacy and toxic side effects of MFL/CAV regimen for advanced breast cancer. Methods Thirty-three patients with advanced breast cancer who can evaluate the efficacy were treated with MFL on the first day: Methotrexate (MTX) 200mg/m~2, 5-fluorouracil (5-Fu) 500mg/m~2, 24 hours After the use of calcium leucovorin (CF) 10mg/m~2 every 6 hours, a total of 6 times, the first 8 days of application of CAV program; cyclophosphamide (CTX) 300mg/m~2, doxorubicin (ADM ) 50mg/m~2 Vincristine (VCR) 1mg/m~2, 28 days for a course of treatment. Results The total effective rate was 81.80% (27/33), of which complete remission (CR) was 9.10%, partial remission (PR) was 72.7%, stability (SD) was 12.1%, and progression (PD) was 6%. The median remission period was 11 months and the median response was 2 courses of treatment. The toxic side effects were mainly myelosuppression, recovery from 3 to 4 weeks, followed by gastrointestinal reactions and hair loss. Conclusion The use of MFL/CAV regimen is one of the most effective regimens for the treatment of advanced breast cancer.