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目的了解耐甲氧西林金黄色葡萄球菌(MRSA)医院感染临床分布及耐药情况,为临床合理用药提供参考依据。方法采用标本检验和药敏试验方法,对病人标本进行MRSA分离鉴定和药敏试验,并对结果进行分析。结果从病人标本中分离的320株金黄色葡萄球菌中检出MRSA 68株,检出率为21.3%。MRSA菌株主要分离自痰液和咽拭子标本,占61.8%;其次是脓液,占16.2%。MRSA感染患者主要来源科室为ICU和神经外科居多。临床分离的MRSA对苯唑西林、青霉素G耐药率100%;对红霉素、四环素耐药率>50%。结论该医院MRSA感染者主要分布于ICU,以痰标本和咽拭子分离率最高,MRSA普遍耐药。
Objective To understand the clinical distribution and drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) in hospital and provide a reference for clinical rational drug use. Methods The specimens were tested by MRSA and susceptibility test by MRSA. The results were analyzed. Results A total of 68 strains of MRSA were detected in 320 Staphylococcus aureus isolates from patients. The detection rate was 21.3%. MRSA strains were mainly isolated from sputum and throat swab specimens, accounting for 61.8%; followed by pus, accounting for 16.2%. The majority of MRSA-infected patients are ICU and neurosurgical departments. MRSA isolates of oxacillin and penicillin were 100% resistant to erythromycin and tetracycline. Conclusion The MRSA patients in this hospital are mainly located in the ICU, with the highest rate of sputum and throat swab separation, and MRSA is generally resistant.