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布氏杆菌在体外实验中虽对大多数抗菌药物具有一定程度的敏感性,但该菌侵入人体后寄生于巨噬细胞和网状内皮细胞内,致使不同药物的临床治疗效果差别较大。西班牙某医院在1980～1987年间对近期患布氏杆菌病者随机采用不同抗菌治疗方案,通过随访观察,比较各自的疗效和不良反应,以期能筛选出较为适当的治疗方法。病人总数330例,男242例,女88例;年龄在14～82岁间,平均46岁。多数患者病前饮用过未经消毒处理的牛奶或奶酪,其余有
Although Brucella is sensitive to most antibacterials in vitro, the bacteria invade the human body and parasitize macrophages and reticuloendothelial cells, resulting in different clinical effects of different drugs. A Spanish hospital from 1980 to 1987 recently suffered from brucellosis patients with different antimicrobial treatment options, by follow-up observation, compare their efficacy and adverse reactions, in order to screen out the more appropriate treatment. The total number of patients 330 cases, 242 males and 88 females; aged 14 to 82 years, mean 46 years. The majority of patients had previously consumed unsterilized milk or cheese and the rest had