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目的 :探讨口腔颌面鳞癌术前诱导化疗二种方式应用的疗效、主要毒副反应差别 ,以及临床适应证。为术前诱导化疗的选择提供临床指导。方法 :本文回顾了 1 0 4例可评价近期疗效的口腔颌面鳞癌术前诱导化疗的病例。其中全身化疗 5 6例 ,颈外动脉插管化疗 48例。结果 :以肿瘤体积缩小 5 0 %以上作为化疗有效指标 ,全身化疗组有效率为 6 4.3%。颈外动脉插管化疗组有效率为79.2 % ,两组总有效率为 71 .2 % (P<0 .0 5 )。全身化疗组的主要毒副反应为胃肠反应、白细胞减少和脱发 ;颈外动脉插管化疗组主要为口腔粘膜溃疡、糜烂及灼痛感。结论 :作为术前诱导的全身化疗较适合于全身状况良好的患者 ,而颈外动脉插管灌注化疗较适合于全身状况稍差、无转移、肿瘤范围不广的患者。
Objective: To investigate the curative effect of two kinds of preoperative chemotherapy induced by oral and maxillofacial squamous cell carcinoma, the main toxic and side effects, and clinical indications. Preoperative induction chemotherapy for the choice of clinical guidance. Methods: This paper reviewed 104 cases of oral and maxillofacial squamous cell carcinoma which could evaluate the short-term effect of preoperative chemotherapy. Among them, 56 cases received systemic chemotherapy and 48 cases received external carotid intubation chemotherapy. Results: To reduce the tumor size of more than 50% as an effective indicator of chemotherapy, systemic chemotherapy group was effective rate of 4.3%. The effective rate of external carotid intubation chemotherapy group was 79.2%, the total effective rate was 71.2% (P <0.05). The main side effects of systemic chemotherapy were gastrointestinal reactions, leukopenia and hair loss; external carotid artery chemotherapy group mainly for oral mucosal ulcers, erosion and burning sensation. Conclusion: As a preoperative systemic chemotherapy is more suitable for the general condition of patients, and external carotid artery catheterization chemotherapy is more suitable for the general condition of the lesser, no metastasis, the tumor is not a wide range of patients.