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对于药物的控释,人们广泛进行了人工合成聚合物作为微囊和片剂包衣物料应用的研究。然而这类方法费用高、时间长,还需注意药物和溶剂之间可能的相互作用。微囊的释放速率被认为随衣层的厚度、孔隙度、毛细管作用和囊心颗粒的大小而变化,其分散状态对释放速率也有影响。本文研究一个简单的胶囊填充技术。用一小段对药物无渗透性的硬质聚乙烯管模拟胶囊,管的上、下两端用乙基纤维素薄膜密封。该膜控装置为壁厚1,5mm,内径2cm,长度0.25～1cm 的硬质聚乙烯
For the controlled release of pharmaceuticals, extensive research has been conducted on the use of synthetic polymers as microcapsule and tablet coating materials. However, these methods are costly and time-consuming, with attention also being paid to possible interactions between drugs and solvents. The rate of release of microcapsules is believed to vary with the thickness of the coating, porosity, capillary action, and the size of the capsule particles, and their dispersion also has an effect on the rate of release. This article studies a simple capsule filling technique. Use a short piece of rigid polyethylene tubing that is impervious to the drug to simulate the capsule, with the upper and lower ends of the tube sealed with an ethylcellulose membrane. The membrane control device is a rigid polyethylene with a wall thickness of 1,5 mm, an inner diameter of 2 cm and a length of 0.25 to 1 cm