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Ｃ 肽是胰岛素原转变为胰岛素过程中的裂解产物。近年来的研究显示Ｃ 肽能够预防和逆转糖尿病诱发的血管功能障碍，尤其在特征性糖尿病微血管病变———糖尿病肾病中具有减轻肾小球高滤过状态，减少尿白蛋白漏出的有益效应。Ｃ 肽的作用可能是通过加强胰岛素信号系统的功能、提高组织Ｎａ ＋ 、Ｋ＋ＡＴＰ 酶活性、在膜脂质中形成离子通道改变离子稳态、阻断还原应力引起的代谢失衡或激活内皮细胞一氧化氮合成酶等机制发挥生物效应。Ｃ 肽的研究进展对改善糖尿病的治疗可能有重要意义。
C-peptide is the cleavage product during the conversion of proinsulin into insulin. In recent years, studies have shown that C-peptide can prevent and reverse diabetes-induced vascular dysfunction, especially in the characteristic diabetic microangiopathy --- diabetic nephropathy has to reduce glomerular hyperfiltration state, reduce the beneficial effects of urinary albumin leakage. The role of C-peptide may be to enhance the activity of the Na +, K + -ATPase in the tissue by enhancing the function of the insulin signaling system, forming ion channels in membrane lipids to alter ionic homeostasis, blocking the metabolic imbalance caused by reducing stress, or activating endothelial cells Nitric oxide synthase mechanisms play a biological effect. The research progress of C-peptide may have important significance to improve the treatment of diabetes.