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p53基因的变化已被认为是肿瘤病因学和分子发病机制的重要线索。为了阐明HCC的主要致病因子及其在HCC发病机制中的相对意义，本研究对p53基因变化较常见的中国南部地区的70例HCC患者采用x2检验等，分析一般资料、嗜肝病毒感染和病理资料与p53基因变化的关系。结果显示，p53基因的密码子249突变与AFP阳性、HCC分化程度、HCC高度流行区、嗜肝病毒感染以及HBVDNA在癌组织中存在等因素密切相关。p53基因的LOH则与嗜肝病毒感染和癌周组织中的肝硬化程度相关。以上结果提示，HCC的主要致病因素是嗜肝病毒感染和高度流行区的某些其它因素，其中嗜肝病毒感染在HCC的病因学和分子发病机制中的意义更为重要。
The alteration of p53 gene has been considered as an important clue to tumor etiology and molecular pathogenesis. In order to elucidate the main virulence factors of HCC and its relative significance in the pathogenesis of HCC, in this study, the x2 test was used to analyze the general data and the hepatotropic virus infection in 70 patients with HCC in southern China where the p53 gene mutation was more common. The relationship between pathological data and p53 gene changes. The results showed that the codon 249 mutation of p53 gene was closely related to factors such as AFP positive, HCC differentiation, HCC highly endemic area, hepatotropic virus infection, and HBV DNA in cancer tissues. The LOH of the p53 gene is related to the degree of hepatotropic virus infection and cirrhosis in the pericancerous tissue. The above results suggest that the main pathogenic factors of HCC are hepadnavirus infections and certain other factors in highly endemic areas. The significance of hepatotropic virus infection in the etiology and molecular pathogenesis of HCC is even more important.