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目的 探讨影响非小细胞肺癌术后早期复发的临床病理因素 ,了解血清癌胚抗原(CEA)检测对预测非小细胞肺癌患者术后早期复发的作用。方法 对 2 0 0 0年 9月～ 2 0 0 2年 8月收治的 93例非小细胞肺癌患者行手术治疗 ,术前行血清CEA测定 ,术后随访 1年以上 ,记录第 1次复发的时间。应用Logistic回归分析观察影响非小细胞肺癌术后早期复发的临床病理因素 ,应用受试者工作特征 (ROC)曲线进行数据分析 ,比较各危险因素预测非小细胞肺癌术后早期复发的能力。结果血清CEA水平、临床分期和肿瘤分化与非小细胞肺癌术后早期复发有关。其中CEA >10 μg/L是预测非小细胞肺癌术后早期复发较好的指标 (ROC曲线下面积 :0 84 3,95 %CI :0 72 3～ 0 96 3,P =0 0 0 0 )。结论 对于可以手术切除的非小细胞肺癌患者 ,术前应行血清CEA水平测定 ,术前血清CEA >10 μg/L提示 ,术后复发的可能性较大
Objective To investigate the clinicopathological factors influencing the early postoperative recurrence of non-small cell lung cancer (NSCLC) and to find out the effect of serum carcinoembryonic antigen (CEA) in predicting the early postoperative recurrence in non-small cell lung cancer patients. Methods Seventy-three patients with non-small cell lung cancer who were treated from September 2000 to August 2002 underwent surgical treatment. Serum CEA was measured preoperatively and was followed up for more than one year. The first recurrent time. Logistic regression analysis was used to observe the clinicopathological factors influencing the early postoperative recurrence of non-small cell lung cancer (NSCLC). The ROC curve was used to analyze the data and each risk factor was compared to predict the early postoperative recurrence of non-small cell lung cancer. Results Serum CEA level, clinical stage and tumor differentiation were correlated with early postoperative recurrence of non-small cell lung cancer. CEA> 10 μg / L is a good predictor of early postoperative recurrence of non-small cell lung cancer (ROC area: 0 843, 95% CI: 0 723 to 0 963, P = 0 0 0 0) . Conclusion For patients with resectable non-small cell lung cancer, serum CEA levels should be measured preoperatively. Preoperative serum CEA> 10 μg / L suggests that the probability of recurrence after surgery is higher