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目的探讨经PICC输注两性霉素B治疗血液病合并肺部真菌感染的效果。方法应用两性霉素B治疗血液病并发肺部真菌感染患者20例,以PICC置管途径输注10例为试验组,四肢浅静脉输注10例为对照组。观察两组疗效及不良反应。结果试验组有效8例,对照组有效6例,两组有效率比较差异无统计学意义(P>0.05);试验组未发生静脉炎,对照组发生7例,差异有统计学意义(P<0.05),其他不良反应比较均无统计学差异(P>0.05)。结论经PICC输注两性霉素B治疗血液病合并肺部真菌感染操作方便、并发症少、留置时间长,值得临床推广应用。
Objective To investigate the effect of PICC transfusion of amphotericin B in the treatment of hematological and pulmonary fungal infections. Methods 20 cases of pulmonary fungal infection were treated with amphotericin B, 10 cases were infused with PICC catheter and 10 cases were infused with superficial veins. The curative effect and adverse reaction of two groups were observed. Results There were 8 effective cases in the trial group and 6 cases in the control group. There was no significant difference between the two groups (P> 0.05). There was no phlebitis in the experimental group and 7 cases in the control group (P < 0.05). There was no significant difference in other adverse reactions (P> 0.05). Conclusion PICC infusion of amphotericin B in the treatment of blood diseases associated with pulmonary fungal infection is easy to operate, less complications, indwelling a long time, worthy of clinical application.