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目的观察分析老年慢性心力衰竭患者使用单硝酸异山梨酯对血浆BNP水平的影响。方法患者均为NYHA分级为Ⅱ-Ⅲ级的非瓣膜性心脏病老年慢性心力衰竭患者,随机分为2组,对照组按照指南给予常规治疗,治疗组在常规治疗基础上加用口服单硝酸异山梨酯,采用美国博适Triage检测仪测量患者的血浆BNP的水平含量,比较两组治疗后血浆BNP水平。结果加用口服单硝酸异山梨酯组治疗后血浆BNP水平低于对照组(P<0.05)。结论在常规治疗基础上加用口服单硝酸异山梨酯,可有效改善患者心功能,降低血浆BNP水平,值得医师参考应用。
Objective To investigate the effect of isosorbide mononitrate on plasma BNP levels in elderly patients with chronic heart failure. Methods Patients were all NYHA class Ⅱ-Ⅲ non-valvular heart disease elderly patients with chronic heart failure, were randomly divided into two groups, the control group according to the guidelines for conventional treatment, the treatment group on the basis of conventional treatment plus oral mononitrate Sorbitol, BNP level in plasma was measured by Boer Triage detector. Plasma BNP level was compared between two groups. Results After treatment with isosorbide mononitrate, plasma BNP level was lower than that of the control group (P <0.05). Conclusion Oral administration of isosorbide mononitrate on the basis of routine treatment can effectively improve the cardiac function and reduce plasma BNP levels, which is worthy of reference.