Effects of Smac gene over-expression on the radiotherapeutic sensitivities of cervical cancer cell l

• 出 处: Chinese Medical Journal
• 发表日期: 2005年03期
• 关键词: Smac minutes Caspase downstream TRAIL AnnexinV tubulin invitro upstream caspase

Background The second mitochondria-derived activator of caspases (Smac) is a novel proapoptotic gene, which plays an important role in the apoptosis-inducing effects of irradiation on tumor cells. The purpose of this study was to investigate the effects of extrinsic Smac gene transfer and its over-expression in radiotherapeutic sensitivities of cervical cancer cells.

Background The second mitochondria-derived activator of caspases (Smac) is a novel proapoptotic gene, which plays an important role in the apoptosis-inducing effects of irradiation on tumor cells. The purpose of this study was to investigate the effects of extrinsic Smac gene transfer and its over-expression in radiotherapeutic sensitivities of cervical cancer cells.