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In the femoral head necrosis model rabbit induced by endotoxin combined with methylprenisolone, thedynamical changes of plasma TXB_2 and 6-keto-PGF_(1α)contents were observed. As a result, microscopicexamination showed that in the model group, bone trabeculae became fine, empty bone lacunae increased,and osteoblasts in number decreased; the ratio of TXB_2 and 6-keto-PGF_(1α) was out of balance, and thesechanges worsened gradually with the lapse of time; Compound Sheng Mai Cheng Gu Capsules (复方生脉成骨胶囊) could reverse femoral head necrosis, protect the vascular endothelial cells, recover the balanceof TXB_2 and 6-keto-PGF_(1α). It is concluded that the hormone-induced femoral head necrosis is closelyrelated with blood stasis, and that the Chinese drugs for activating blood circulation and removing bloodstasis can prevent the femoral head from development of necrosis.
In the femoral head necrosis model rabbit induced by endotoxin combined with methylprenisolone, thedynamical changes of plasma TXB_2 and 6-keto-PGF_(1α)contents were observed. As a result, microscopicexamination showed that in the model group, bone trabeculae became fine, empty Bone lacunae increased, and osteoblasts in number decreased; the ratio of TXB_2 and 6-keto-PGF_(1α) was out of balance, and these changess worsened gradually with the lapse of time; Compound Sheng Mai Cheng Gu Capsules胶囊) can reverse femoral head necrosis, protect the vascular endothelial cells, recover the balanceof TXB_2 and 6-keto-PGF_(1α). It is concluded that the hormone-induced femoral head necrosis is closely related with blood stasis, and that the Chinese drugs For activating blood circulation and removing bloodstasis can prevent the femoral head from development of necrosis.